LGF-1 DES 1 3 Human Growth Hormone Steroids Peptide For Muscle
We can supply IGF DES 1 , 3
Product: IGF-1 DES 1,3
Unit Size: 1 mg/vial
Molecular Weight: 7371.4
Appearance: White Powder
Synonyms: IGF-1 DES
Des(1-3)IGF-1 is a naturally occurring, endogenous protein, as well
as drug. The amino acid sequence of des(1-3)IGF-1 is TLCGAELVDA
LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA.
Insulin Like Growth Factor (IGF)-1 (4-70), otherwise known as IGF-1
DES, produced in E. coli, is a single, non-glycosylated,
polypeptide chain containing 67 amino acids and having a molecular
mass of 7,372 Da. In vitro studies demonstrate that at equal doses
DES (1-3) IGF is ten times more potent than IGF-1 at stimulating
hypertrophy and proliferation in cultured cells. It is likely
generated through post-translational modification in the sequence
of circulating mature IGF-1 via protease action.
IGF-1 DES is a cleaved form of IGF-1 and contains amino acids 4-70.
This structure has allowed the effects of the IGF-1 protein to be
amplified in the more stable form of the DES 1,3 molecule peptide
protein fragment of Insulin-like growth factor 1. The IGF-1 DES, or
insulin-like growth factor DES, comes from the IGF-1 family of
peptides that play important roles in mammalian growth and
development. IGF1 mediates many of the growth-promoting effects of
growth hormone and IGF-1 DES, although shorter, pacts an equal
amount of physiological altering protein physical changes. Early
studies showed that growth hormone did not directly stimulate the
incorporation of sulfate into cartilage, but rather acted through a
serum factor, termed 'sulfation factor,' which later became known
as 'somatomedin' or IGF-1 and more recently through truncation, DES
IGF-1 (Insulin-like growth factor) is an endocrine hormone that is
produced in the liver. The production of IGF-1 is increased in the
presence of growth hormone. There are many different types of cells
in the body that are equipped with a receptor to accept IGF-1. This
makes IGF-1 a good protagonist at targeting tissues to spur cell to
cell communication (growth) or in a more autocrine cell signaling
process that facilitates cell division.
Why is this IGF-1 important for a bodybuilder or athlete? Let’s
take a look at the list:
- Helps regulate fat for use as energy, resulting in fat loss.
- Contributes to anti aging. As we get older, IGF-1 production slows
down and this results in cell reduction. Low levels of IGF-1 are
linked to heart failure, lower brain cell regulation and neuron
function. Not to mention muscle tissue breakdown.
- Helps to increase nutrient shuttling (protein synthesis).
- Increases regenerative functions of nerve tissues.
- Boosts the ability to cause hyperplasia in muscle cells resulting
in fuller muscle tissue.
Fig 1. IGF-1 Chemical Structure
Why use IGF-1?
To put it simply, the gains from IGF-1 (all variants) are not due to water weight, so the gains you will
achieve will be long term muscle growth. This is compared to
steroids, which are renowned for putting on water weight and giving
you nasty side effects. You are not going to gain 10lbs from using
IGF-1, but you will see solid 1-2lbs gains every 1-2 weeks.
The most important factor to consider is IGF-1’s ability to achieve
hyperplasia. When you use steroids, they will help the body through
hypertrophy, which means you are increasing the size of the
existing muscle cells. On the other hand, IGF-1 will cause
hyperplasia, which means you are actually increasing the number of
cells in the muscle tissue. These new cells can be utilized through
further training, and use of steroids, to make bigger muscles.
Essentially, you will have the ability to achieve more muscle
density and size at the genetic level by using IGF-1.
IGF-1 variants are split into two groups: IGF-1 LR3 and DES IGF-1
(usually presented as IGF-1 DES). Base IGF-1 has a very short half
life (about 10-20 minutes); as a result, it is quickly destroyed by
the body. This is why IGF-1 was modified to make the amino acid
analog IGF-1 LR3 (Long). The other variant of IGF-1 called DES
IGF-1 is a truncated version that is 10X more potent than IGF-1.
Both variants are similar to its root but have different actions,
allowing them to function in a specific ways.
IGF-1 LR3 has a half-life of about 20-30 hours and is much more
potent than base IGF-1. Since its half-life is about a day, the
IGF-1 LR3 will circulate the body, for around 24 hours, binding to
receptors and activating cell communication that improves muscle
growth and fat loss.
LR3 prevents glucose from entering into cells, which, in turn,
forces the body to burn fat and not sucrose. In addition, its long
half-life is desirable for another reason; site injections aren't
necessary, as IGF-1 LR3 will cycle the body binding to all muscle
cells for about a day.
DES IGF-1 is the shorter version of the IGF-1 chain. It is five (5)
times more powerful than IGF-LR3 and ten (10) times more powerful
than regular base IGF-1. The half-life for DES is about 20-30
minutes, which means this is a very delicate chain. Therefore,
administration should only be done at the site where you want to
see muscle growth. DES has the ability to stimulate muscle
hyperplasia better than LR3. In simple terms, it's best used for
site injections, rather than overall growth.
In addition, DES is known to bind to receptors that have been
deformed by lactic acid, which is often present during workouts.
This allows the DES to attach itself to a mutated receptor and
signal tissue growth during training. DES can be used longer and
more frequently than LR3.
IGF-1 vs. HGH
Why IGF-1 and not GH? Growth hormone actually is a precursor to IGF-1. Growth hormone
does not directly cause muscle growth, but indirectly causes muscle
growth by signaling the release of IGF-1. Human Growth Hormone (HGH) can be very expensive, and to see muscle growth it needs to be
paired with insulin or other anabolic steroids. This makes IGF-1 variants like LR3 and DES, which can be used as
a standalone drug, a much more viable option for bodybuilder
looking to see solid recovery of damaged tissue and muscle growth.
Fig 2. HGH signals IGF-1 Production
Dosing and Injections
IGF-1 LR3 can be taken 7 days a week at a dose of 50-150mcg a day.
Desensitization was shown to occur at around 40 days or roughly 4
weeks. Injection sites can be at any muscle group on the body, as
it's not very good at site specific growth.
DES IGF-1 can be dosed at 50-150mcg multiple times a day (prior to
training) into specific target areas. since DES has such a short
half life (20-30 minutes), desensitization was not noticed at all .
Injection sites should be localized; preferably, at the muscle
group you want to grow. In simple terms, if you want to grow your
biceps, inject IGF-1 DES right into your bicep.
It should be noted that high doses of IGF-1 have been known to
cause hypoglycemia, but nowhere near the level of insulin. It is
also noted, and highly debated, that IGF-1 was shown to increase
tumor size in cancer patients. While this fact may be true in
patients with existing cancer, IGF-1 is not the cause of cancer; in
fact, our bodies need IGF-1 to regulate heart function, nervous
system and brain cell stimulation. People with low IGF-1 levels
were found to have low protein counts and low lean body mass,
which, in turn, can be equally unhealthy. If you have a headache,
you don’t take a whole bottle of Aspirin. Likewise, to guard
yourself from making ignorant mistakes, IGF-1 should be
administered properly , and never abused.